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Home/Guides & Tips/Weight loss/

Ozempic side effects

Ozempic side effects: Is it safe?

Like all medicines, Ozempic can cause side effects, though they’re mild and manageable for most people. Here’s what you need to know.


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Medically reviewed by

Dr Earim Chaudry (MBBS), Chief Medical Officer

iconPublished 9th October 2025
Research-Based Guide
Table of contents
  • Most common side effects of Oz...
  • What are the worst Ozempic sid...
  • Do Ozempic side effects go awa...
  • How to manage the side effects...
  • Who shouldn’t use Ozempic?
  • Can you take Ozempic with high...
  • Is Ozempic safe?
  • Your weight loss journey

With all the interest in Ozempic, there’s been some talk around its side effects. For example, you might have seen the terms “Ozempic face” or “Ozempic mouth” in the media (these aren’t medical terms nor official side effects of the medicine—and they aren’t anything to be particularly worried about).

So, you might be wondering: is Ozempic safe? For most people who meet the prescribing criteria, the answer is yes. Here’s what you need to know.

By the way: Ozempic and Wegovy are different brand names for the same medicine: semaglutide. Ozempic is licensed for type 2 diabetes, though it’s used off-label for weight. Whereas Wegovy is approved for weight loss.

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Struggling to reach your target weight? You’re not alone. Find out about how medications like Wegovy can boost your efforts and get you closer to your health goals.
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Most common side effects of Ozempic

Over one in ten people taking Ozempic might get side effects. Mostly, these are mild and clear up on their own.

Common side effects include:

  • Nausea
  • Diarrhoea
  • Vomiting
  • Constipation
  • Flatulence
  • Fatigue

FYI: all medicines have side effects. And a qualified provider will weigh up the “negatives” of Ozempic (side effects) against its potential benefits when deciding to prescribe it. They won’t give it to you if they don’t think it’s safe for you to take.

What are the worst Ozempic side effects?

It’s uncommon, but Ozempic can sometimes bring on more serious side effects.

Pancreatitis

The pancreas can become inflamed in up to 1% of people taking Ozempic. If you experience severe pain in your back or stomach that doesn’t go away, see your doctor asap.

Allergic reaction

Up to 0.1% of people may have an allergic reaction to Ozempic. Here, your face, lips, tongue and throat might swell up, causing difficulty breathing. If that’s you, seek help immediately.

Side effects support at Voy

"If you're using Voy and you experience any side effects, rest assured that our expert clinicians are just a message or phone call away. They can adjust your dose, prescribe medication to ease your symptoms, or simply offer reassurance.

Everyone responds differently to weight loss treatment and we'll help you find what feels right for you."

Phoebe Fox - Weight Loss Specialist Clinician

Do Ozempic side effects go away?

Most of the time, yes. Symptoms are usually mild to moderate and sort themselves out after a few lifestyle changes.

Everyone reacts to medicine differently, but to give you an idea of how long that might take: in clinical research on semaglutide, nausea, diarrhoea and vomiting cleared within a few days.

If your symptoms stick around, or if you think you have any of the serious side effects we mentioned above, it’s best to see a doctor.

How to manage the side effects of Ozempic

We’re happy to report that Ozempic side effects are usually pretty manageable.

If you’re dealing with diarrhoea or vomiting, make sure you get plenty of rest and drink lots of fluids. Getting some fresh air, or sipping a mug of ginger or peppermint tea, might help with nausea.

Steering clear of food and drink that might upset your stomach is also a good idea. For example, greasy or spicy foods, caffeine or fizzy drinks.

But to reiterate: if your symptoms don’t go away, are bothering you or getting worse, check in with your provider.

Who shouldn’t use Ozempic?

Your provider will review your medical history and decide whether Ozempic is right for you. But it’s not recommended if you’re pregnant or breastfeeding, or if you have a personal or family history of either multiple endocrine neoplasia syndrome type 2 (MEN2) or thyroid cancer.

Can you take Ozempic with high blood pressure?

Great question. Having high blood pressure, aka hypertension, doesn’t disqualify you from taking Ozempic (or Wegovy weight loss injections).

In fact, studies show that semaglutide has many other benefits beyond weight loss and may even help to lower blood pressure.

This may be particularly good news for people with type 2 diabetes. Hypertension is twice as common in people with diabetes compared to those without the disease—and both conditions are related to being overweight. In studies of people with type 2 diabetes, semaglutide not only helped with weight loss but also improved blood pressure.

Is Ozempic safe?

Yes, Ozempic is generally reported to be well-tolerated with manageable side effects.

One review of six clinical trials, which included 3,962 participants in total, concluded that while side effects were common they were mostly mild to moderate and typically only lasted a few days.

Data taken from people using semaglutide in the real world echoes these findings: Ozempic/Wegovy side effects are largely mild.

Your weight loss journey

If you’re feeling stuck in your weight loss journey—we see you. It can be difficult to lose weight through lifestyle change alone.

Weight loss medication may be able to help. And you can get weekly medication posted to you, plus lifestyle guidance from our clinicians and coaches, through our weight loss programme. We don’t offer Ozempic for weight loss but have plenty of alternatives: Wegovy and Mounjaro weight loss injections are available.

Take our quiz to see if you’re eligible.

Looking to start your weight loss journey?
Take a quick eligibility quiz to explore your options and see how we can support you.
FAQ

FAQs about side effects

Dr Earim Chaudry, MBBS
DisclaimerAt Voy, we ensure that everything you read in our blog is medically reviewed and approved. However, the information provided is not meant to replace professional medical advice, diagnosis, or treatment. It should not be relied upon for specific medical advice.
References
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Andreadis, Panagiotis, et al. “Semaglutide for type 2 diabetes mellitus: a systematic review and meta-analysis,” Diabetes, Obesity and Metabolismscribble-underline, vol. 20, issue 9, 2018:2255-2263 https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.13361

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Electronic Medicines Compendium. “Ozempic: information for the patient.” Medicines.org.uk,scribble-underline 2025 https://www.medicines.org.uk/emc/files/pil.9748.pdf Accessed 3 October 2025

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Electronic Medicines Compendium. “Wegovy: information for the patient.” Medicines.org,scribble-underline https://www.medicines.org.uk/emc/files/pil.13800.pdf Accessed 3 October 2025

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Garvey, Timothy W, et al. “Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial.” Nature Medicinescribble-underline, vol. 28, 2022:2083-2091 https://www.nature.com/articles/s41591-022-02026-4 Accessed 3 October 2025

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Kang, Da-Hyun, et al. “Telogen effluvium associated with weight loss: a single center retrospective study,” Annals of Dermatologyscribble-underline, vol. 36, no. 6, 2024:384-388 https://pmc.ncbi.nlm.nih.gov/articles/PMC11621640/

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Lincoff, Michael A., et al. “Semaglutide and cardiovascular outcomes in obesity without diabetes,’ The New England Journal of Medicine,scribble-underline vol. 389, no. 24, 2023:2221-2232 https://www.nejm.org/doi/full/10.1056/NEJMoa2307563

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National Health Service. “Diarrhoea and vomiting,” NHS.ukscribble-underline, 2023

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https://www.nhs.uk/symptoms/diarrhoea-and-vomiting/ Accessed 3 October 2025

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National Health Service. “Feeling sick (nausea),” NHS.uk,scribble-underline 2023 https://www.nhs.uk/symptoms/feeling-sick-nausea/ Accessed 3 October 2025

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Novo Nordisk. “Ozempic: important safety information.” Ozempic.com,scribble-underline https://www.ozempic.com/important-safety-information.html Accessed 3 October 2025

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Petrie, John R., et al. “Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms.” Canadian Journal of Cardiology,scribble-underline vol. 34, no. 5, 2018:575-584 https://pmc.ncbi.nlm.nih.gov/articles/PMC5953551/

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Quin, Wenhui, et al. “Efficacy and safety of semaglutide 2.4 mg for weight loss in overweight or obese adults without diabetes: An updated systematic review and meta-analysis including the 2-year STEP 5 trial,” Diabetes, Obesity and Metabolismscribble-underline, vol. 26, issue 3, 2023:911-923 https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.15386

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Rivera, Frederick Berro, et al. “Evaluating the safety profile of semaglutide: an updated meta-analysis,” Current Medical Research and Opinionscribble-underline, vol. 40, issue. 9, 2024:1495-1514 https://www.tandfonline.com/doi/10.1080/03007995.2024.2383731

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Ryan, Donna H, et al. “Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial.” Nature Medicinescribble-underline, vol. 30, no. 7, 2024:2049-2057 https://pmc.ncbi.nlm.nih.gov/articles/PMC11271387/

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Wharton, Sean, et al. “Gastrointestinal tolerability of once‐weekly semaglutide 2.4 mg in adults with overweight or obesity, and the relationship between gastrointestinal adverse events and weight loss,” Diabetes, Obesity and Metabolism,scribble-underline vol. 24, no. 1, 2021:94-105 https://pmc.ncbi.nlm.nih.gov/articles/PMC9293236/

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Yale, Jean-François, et al. “Real-world safety profile of once-weekly semaglutide in people with type 2 diabetes: Analysis of pooled data from the SemaglUtide Real-world Evidence (SURE) programme,” Diabetes, Obesity and Metabolismscribble-underline, vol. 26, issue 10, 2024:4429-4440 https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.15794

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